Alpha-2-Macroglobulin for Arthritis



Imagine how wonderful it would be if your body had the capability to carry it’s own biologic treatment within the bloodstream to treat your arthritic knee. Wouldn’t that be incredible? The good news is this: Your body already has the tools it needs to combat degeneration caused by arthritis, and it’s called Alpha-2-Macroglobulin, or A2M for short. A2M is one of the many leading-edge regenerative medical procedures offered at Paradigm Wellness Medical Group.

But what is Alpha-2-Macroglobulin and where does it come from? A2M is a large plasma protein, your liver makes it, and it is found in your blood. A2M is among the largest and heaviest proteins that your body makes. It is a naturally occurring plasma glycoprotein whose principal activity is to counteract the protein/enzymes called “proteases” that break down various chemicals and molecules no longer needed in your body in a well-balanced chain of events that keeps you healthy. According to the Mayo Clinic, A2M transports hormones and enzymes, exhibits effector and inhibitor functions in the development of the lymphatic system, and inhibits components of the complement system and hemostasis system.

Scientific research out of Brown University has discovered that A2M could be the key to stopping osteoarthritis at the molecular level. Research shows that if A2M is concentrated and injected into the arthritic joint, the A2M protects the cartilage and stops the progression of arthritis. According to the research findings, A2M could help prevent arthritis in the affected joints after ACL repair. Also, there is data suggesting that there is a regenerative component to A2M which can further help the joint, spinal disc or soft tissue recover. This is great news for patients interested in using regenerative medicine procedures to combat arthritis!

“Alpha 2 macroglobulin (A2M) uses the most advanced science to not only stop osteoarthritis at its source, but also protect you from a protein complex that causes your joints to ache.” –Gaetano Scuderi, M.D.

Many medical professionals are excited by this news because Osteoarthritis affects millions of Americans. To put it into perspective, here are some statistics from Cytonics Corporation:

“The Centers for Disease Control estimates that some 27 million adult Americans are afflicted with osteoarthritis. Furthermore, it is estimated that 1 in 2 adults will get symptomatic knee osteoarthritis in their lifetime. With the combination of the aging Baby Boomer population, increased longevity of U.S. citizens and the obesity epidemic, the rising prevalence of OA is expected to contribute even more heavily to the severe health and economic effects already present. Osteoarthritis often causes weakness and disability, interferes with work productivity, and often results, ultimately, in joint replacement.”

Paradigm Wellness Medical Group is excited to offer this new injectable therapy for arthritis. Brown University’s research shows that A2M could be a master inhibitor of cartilage-degrading enzymes. Supplemental injections of alpha-2-macroglobulin into the painful joints or lumbar discs could diminish cartilage degeneration and may be a potential therapy for osteoarthritis and disc degeneration. If Paradigm Wellness Medical Group can inject more of this protein into an arthritic joint early in the arthritic process before too much destruction occurs, it is possible to slow down, if not halt, the progression of joint deterioration.

Therefore, Alpha-2-Macroglobulin could be the first truly biologic treatment for a condition that has plagued millions of Americans for a long time. Still, it is important to consult with Paradigm Wellness Medical Group to determine if you are a good candidate for A2M injection therapy or other regenerative medicine treatments.

Dr. Joe Cleaver and Gina Knudsen, co-founders of Paradigm Wellness Medical Group, are passionate about helping their patients achieve a healthy lifestyle and optimize wellness through fitness, nutrition, and education. Together, they offer 40 years of combined conventional and integrative medical experience. They have offices San Francisco, Santa Rosa, and Dallas; plus the Sonoma Valley winery. Contact us for a consultation and let us explore together how we can help you look and feel your best naturally.